NOC:Structure, Stereochemistry and Reactivity of Organic Compounds and Intermediates: A Problem Solving Approach

Media Storage Type : 32 GB USB Stick

NPTEL Subject Matter Expert : Prof. A. Basak

NPTEL Co-ordinating Institute : IIT Kharagpur

NPTEL Lecture Count : 40

NPTEL Course Size : 7.3 GB

NPTEL PDF Text Transcription : Available and Included

NPTEL Subtitle Transcription : Available and Included (SRT)

Lecture Titles:

Lecture 1 - Introduction to structure and stereochemistry of organic molecules: salient features of symmetry elements; Role of principal axis, sigma plane, centre of symmetry, and alternating axis of symmetry in deciding chirality
Lecture 2 - Introduction to point group notation, classification, symmetry number and order
Lecture 3 - Examples of various point group notations, chiral and achiral point groups, examples of various point groups
Lecture 4 - Solving problems on point groups (Cn, Cnv, Cnh, Dnd)
Lecture 5 - Conformational Analysis of Perhydrophenanthrene
Lecture 6 - Concept Clearing Session on Achiral Point Groups
Lecture 7 - Axial, Planar and Helical Chirality, assignment of absolute configuration to such molecules
Lecture 8 - Concept of pseudoasymmetry; Reflection variance/invariance problem; methods of nomenclature system
Lecture 9 - Conformational analysis of bicyclic systems: the Decalins
Lecture 10 - Conformational analysis of Perhydrophenanthrene
Lecture 11 - Conformational analysis of Perhydroanthracene
Lecture 12 - Revisiting conformational analysis of Perhydrophenanthrene
Lecture 13 - Revisiting conformational analysis of Perhydroanthracene
Lecture 14 - Introduction to Linear Polarized light and interaction with chiral materials; Circular Birefringence, Circular Dichroism
Lecture 15 - ORD, CD and Cotton Effect (CE); Empirical rule to determine the sign of CE, 2-axial haloketone rule
Lecture 16 - Octant rule: application to substituted cyclohexanone and decalone system
Lecture 17 - Application of Octant rule to tricyclic system; drawing of octant projection
Lecture 18 - Application of Octant rule to steroidal ketones; drawing of octant projection
Lecture 19 - Stereoelectronic effects on conformation and reactivity
Lecture 20 - Examples of anomeric effect and Stereoelectronic effect
Lecture 21 - Baldwin rules
Lecture 22 - Cyclization in enolic systems
Lecture 23 - Problem solving on Baldwin rules
Lecture 24 - Reactive Functionalities: Chemistry of Alkynes
Lecture 25 - Reactive Functionalities: Chemistry of Alkynes (Continued...), arynes and enediynes
Lecture 26 - Reactive Functionalities: Enediynes (Continued...), allenes and Ketenes
Lecture 27 - Beta - Lactam Synthesis
Lecture 28 - Chemistry of radicals
Lecture 29 - Reactivity of radicals: Frontier orbital approach.
Lecture 30 - Radical mediated C-C bond formation
Lecture 31 - Radical mediated C-C bond formation (Continued...).
Lecture 32 - Radical mediated decarboxylation and deoxygenation
Lecture 33 - Dynamic Stereochemistry: Conformationally rigid and mobile systems
Lecture 34 - Dynamic Stereochemistry: Conformational analysis of elimination and addition
Lecture 35 - Dynamic Stereochemistry: Stereoselectivity in carbonyl reduction
Lecture 36 - Dynamic Stereochemistry: Reactivity of unsaturated carbonyl and enolate systems
Lecture 37 - Dynamic Stereochemistry: Enolate as nucleophile
Lecture 38 - Dynamic Stereochemistry: stereochemical issues in cyclohexenone reduction and alpha-electrophilic substitution in carbonyls
Lecture 39 - Dynamic Stereochemistry: Asymmetric aldol reactions
Lecture 40 - Dynamic Stereochemistry: Asymmetric aldol reaction (Continued...)