Bio-Organic Chemistry of Natural Enediyne Anticancer Antibiotics

Media Storage Type : DVD-ROM

NPTEL Course Name : Bio-Organic Chemistry of Natural Enediyne Anticancer Antibiotics

NPTEL Subject Matter Expert : Dr. S.S. Bag

NPTEL Co-ordinating Institute : IIT Guwahati

NPTEL Lecture Count : 63

Lecture Titles:

Lecture 1 - History of Discovery of Enediynes and History of Cancer
Lecture 2 - Microbial Drug Discovery and Isolation of Enediynes
Lecture 3 - Molecular Structures of Enediynes
Lecture 4 - Biological Properties and Mechanisms of Action of Naturally Occurring Enediynes
Lecture 5 - The Bergman Cyclisation Reaction - Part 1
Lecture 6 - The Bergman Cyclisation Reaction - Part 2
Lecture 7 - The Bergman Cyclisation Reaction - Part 3
Lecture 8 - The Bergman Cyclisation Reaction - Part 4
Lecture 9 - The Myers-Saito Cyclisation Reaction - Part 1
Lecture 10 - The Myers-Saito Cyclisation Reaction - Part 2
Lecture 11 - Classifications of Natural Enediynes
Lecture 12 - Mechanism of DNA Cleavage by Each Class
Lecture 13 - Chemical Synthesis of a Few Members of Enediynes Natural Products (Synthesis of Neocarzinostatin) - Part 1
Lecture 14 - Chemical Synthesis of a Few Members of Enediynes Natural Products (Synthesis of Calicheamicin) - Part 2
Lecture 15 - Chemical Synthesis of a Few Members of Enediynes Natural Products (Synthesis of Calicheamicin) - Part 3
Lecture 16 - Chemical Synthesis of a Few Members of Enediynes Natural Products (Synthesis of Dynemicin A) - Part 4
Lecture 17 - Chemical Synthesis of a Few Members of Enediynes Natural Products (Synthesis of N1999A2) - Part 5
Lecture 18 - Chemical Synthesis of a Few Members of Enediynes Natural Products (Synthesis of Kedarcidin Chromophore-Hiramaï¾’s Approach) - Part 6
Lecture 19 - Chemical Synthesis of a Few Members of Enediynes Natural Products (Synthesis of Kedarcidin Chromophore-Myersï¾’ Approach) - Part 7
Lecture 20 - Biosynthesis of a Few Members of Natural Enediynes (Synthesis of Maduropeptin) - Part 8
Lecture 21 - Biosynthesis of a Few Members of Natural Enediynes - Part 1
Lecture 22 - Biosynthesis of a Few Members of Natural Enediynes (General Biosynthesis) - Part 2
Lecture 23 - Biosynthesis of a Few Members of Natural Enediynes (Biosynthesis of C-1027) - Part 3
Lecture 24 - Biosynthesis of a Few Members of Natural Enediynes (Biosynthesis of Neocarzinostatin) - Part 4
Lecture 25 - Biosynthesis of a Few Members of Natural Enediynes (Biosynthesis of Maduropeptin) - Part 5
Lecture 26 - Biosynthesis of a Few Members of Natural Enediynes (Biosynthesis of 10-Membered Enediynes , Calicheamicin ?1I) - Part 6
Lecture 27 - Introduction to Structural Features of Enedynes and Factors Affecting the Reactivity of Enediynes
Lecture 28 - Molecular Design of Enediyne Models (Acyclic Enediynes- Structural Representation) - Part 1
Lecture 29 - Molecular Design of Enediyne Models (Acyclic Enediynes-Representative Examples) - Part 2
Lecture 30 - Molecular Design of Enediyne Models (Cyclic Enediynes- Structural Representation) - Part 3
Lecture 31 - Molecular Design of Enediyne Models (Cyclic Enediynes-Representative Examples) - Part 4
Lecture 32 - Various Synthetic Approaches to Acyclic/Cyclic Enediynes
Lecture 33 - Various Synthetic Aprroaches to Cyclic Enediynes - Part 1
Lecture 34 - Various Synthetic Aprroaches to Cyclic Enediynes - Part 2
Lecture 35 - Synthesis of Dienediyne Core of NCS chromophore
Lecture 36 - ?-Lactam as a Molecular Lock of Enediyne: Synthesis of ?-Lactam Fused Enediynes
Lecture 37 - Enediynes with pH-Based Triggering Devices (Category 1-3) - Part 1
Lecture 38 - Enediynes with pH-Based Triggering Devices (Category 4-5) - Part 2
Lecture 39 - Photoswitchable Enediynes (Category 1-2) - Part 1
Lecture 40 - Photoswitchable Enediynes (Category 3-6) - Part 2
Lecture 41 - Biological Actions of Some Synthetic Models
Lecture 42 - Enediyne as a Scaffold for Peptidomimetics
Lecture 43 - Enediyne as Peptide Cleaving Agent
Lecture 44 - Defining Cancer and Its Various Type - Part 1
Lecture 45 - Defining Cancer and Its Various Type - Part 2 and Cancer-Combination Therapies
Lecture 46 - Therapeutic Applications of Enediyne Antitumor Antibiotics
Lecture 47 - The Approved Enediynes for Use as Anticancer Drugs
Lecture 48 - Enediynes Under Clinical Investigation and Immunoconjugates
Lecture 49 - Antibodyï¾–Drug Conjugates
Lecture 50 - Targeted Chemotherapy
Lecture 51 - Antibody-Enediyne Conjugate under Clinical Investigation and Future Prospect and Recent Advances in Enediyne Research
Lecture 56 - Selected References - I
Lecture 57 - Selected References - II
Lecture 58 - Selected References - III
Lecture 59 - Selected References - IV
Lecture 60 - Assignment - I
Lecture 61 - Assignment - II
Lecture 62 - Assignment - III
Lecture 63 - Assignment - IV