NPTEL : Eukaryotic Gene Expression - basics and benefits (Chemistry and Biochemistry)

Co-ordinators : Prof. P.N. Rangarajan


Lecture 1 - Eukaryotic RNA polymerases and basal transcription factors

Lecture 2 - Diversity in core promoter elements

Lecture 3 - Diversity in general transcription factors

Lecture 4 - Proximal & Distal Promoter Elements, Enhancers and Silencers, Gene-specific Regulators

Lecture 5 - Transcription factors - DNA binding domains

Lecture 6 - Transcription factors - Transcription activation domain

Lecture 7 - Role of chromatin in eukaryotic gene regulation

Lecture 8 - Role of histones in eukaryotic gene regulation

Lecture 9 - Role of DNA methylation in eukaryotic gene regulation

Lecture 10 - Chromatin remodelling & gene regulation

Lecture 11 - mRNA processing - Role of RNA Pol II in mRNA capping and mRNA splicing

Lecture 12 - mRNA processing - Role of RNA Pol II in polyadenylation & mRNA editing

Lecture 13 - Regulation of RNA Pol I transcription

Lecture 14 - Regulation of RNA Pol III transcription

Lecture 15 - Signal Transduction Pathways - Introduction

Lecture 16 - Regulation of gene expression by cyclicAMP

Lecture 17 - Regulation of gene expression by second messengers other than cAMP

Lecture 18 - Regulation of gene expression by Protein Kinase C

Lecture 19 - Regulation of gene expression by Growth factors

Lecture 20 - Regulation of gene expression by cytokines

Lecture 21 - Regulation of gene expression by steroid hormones

Lecture 22 - Regulation of gene expression by type II nuclear receptors

Lecture 23 - Mechanism of transcriptional activation by nuclear receptors

Lecture 24 - Gene Regulation during Drosophila Development

Lecture 25 - Signal transduction pathways involved in embryonic development

Lecture 26 - Homeotic genes

Lecture 27 - Epigenetic regulation of gene expression during development

Lecture 28 - Embryonic stem cells and Transcription factor-mediated epigenetic reprogramming

Lecture 29 - Cloning and Expression vectors

Lecture 30 - Eukaryotic protein expression systems - I

Lecture 31 - Eukaryotic protein expression systems - II

Lecture 32 - Eukaryotic protein expression systems - III: Gene expression in mammalian cells using viral vectors

Lecture 33 - Human Gene Therapy

Lecture 34 - DNA vaccines

Lecture 35 - Transgenic animals

Lecture 36 - Transgenic plants

Lecture 37 - Knockout mic

Lecture 38 - Regulation of Eukaryotic Gene Expression by Small RNAs (RNA Interference, RNAi)

Lecture 39 - Genomics & Proteomics

Lecture 40 - Metabolic Engineering & Synthetic Biology