NPTEL : NOC:Principles and Applications of Enolate Alkylation (Chemistry and Biochemistry)

Co-ordinators : Prof. Samik Nanda


Lecture 1 - Enolate generation, structure of enolates and related topic - I

Lecture 2 - Enolate generation, structure of enolates and related topic - II

Lecture 3 - Enolate generation, structure of enolates and related topic - III

Lecture 4 - Different mode of asymmetric induction in enolate alkylation

Lecture 5 - Revisit again, Different mode of asymmetric induction in enolate alkylation

Lecture 6 - Substrate directed stereocontrol in acyclic and cyclic system

Lecture 7 - Substrate directed enolate alkylation in bicyclic system

Lecture 8 - Seebachâ's SRS principle and related systems - I

Lecture 9 - Seebachâ's SRS principle and related systems - II

Lecture 10 - Seebachâ's SRS principle and related systems - III

Lecture 11 - Evans oxazolidinone and related systems - I

Lecture 12 - Evans oxazolidinone and related systems - II

Lecture 13 - Evans oxazolidinone and related systems - III

Lecture 14 - Evans oxazolidinone and related systems - IV

Lecture 15 - Evans oxazolidinone and related systems - V

Lecture 16 - Helmchenâ's auxiliary, Oppolzerâ's sultam based auxiliary

Lecture 17 - Camphor based N-acyloxazolidinones as chiral auxiliary

Lecture 18 - Myerâ's ephedrine, Chiral Weinreb amide equivalents and related systems

Lecture 19 - Myerâ's ephedrine and related systems

Lecture 20 - Chiral Weinreb amide equivalents and related systems

Lecture 21 - Meyerâ's oxazoline based alkylation - I

Lecture 22 - Meyerâ's oxazoline based alkylation - II

Lecture 23 - Meyerâ's bicyclic lactam based enolate alkylation

Lecture 24 - Meyerâ's bicyclic lactam based alkylation

Lecture 25 - Meyerâ's bicyclic lactams, Gleasonâ's bicyclic thioglycolate lactam based systems

Lecture 26 - Few problem solving from Meyerâ's oxazoline/bicyclic lactam based alkylation

Lecture 27 - Schollkopfâ's bis-lactim ether and related systems; Auxiliary induced chiral relay

Lecture 28 - Chiral relay systems in amino acid derived enolate alkylation

Lecture 29 - Wiliams oxazinone, Yamada's chiral glycine enolate and related system

Lecture 30 - Tricycloiminolactone as chiral glycine equivalents

Lecture 31 - Najera's auxiliary, Davies diketopoperazine and related system

Lecture 32 - Enderâ's RAMP/SAMP,Coltartâ's cyclic carbamate hydrazone,Ellmanâ's sulfinamide and related

Lecture 33 - Enderâ's RAMP/SAMP based systems

Lecture 34 - Enderâ's RAMP/SAMP based systems

Lecture 35 - Enderâ's RAMP/SAMP, Coltartâ's cyclic carbamate hydrazone,Ellmanâ's sulfinamide

Lecture 36 - Coltartâ's cyclic carbamate hydrazone and its exploration

Lecture 37 - Memory of chirality in enolate alkylation

Lecture 38 - Organocatalytic methods for enolate alkylation (SOMO activation)

Lecture 39 - Enantioselective alkylation with chiral PTC

Lecture 40 - Overall analysis of the entire discussion