NPTEL : NOC:Genome Editing and Engineering (Biotechnology)

Co-ordinators : Prof. Utpal Bora


Lecture 1 - Introduction: Genes and Genome Organization

Lecture 2 - History and Basics of Genetic Engineering

Lecture 3 - Advantages and Limitations of Genetic Engineering

Lecture 4 - Breakage of Genomic DNA

Lecture 5 - Repair of Genomic DNA

Lecture 6 - Homologous and non homologous recombination

Lecture 7 - Site specific recombination

Lecture 8 - Targeted genetic modification - I

Lecture 9 - Targeted genetic modification - II

Lecture 10 - Basics of Zinc Finger Nucleases

Lecture 11 - Design of Zinc Finger Nucleases for genome editing

Lecture 12 - Applications of Zinc Finger Nucleases - Part A

Lecture 13 - Applications of Zinc Finger Nucleases - Part B

Lecture 14 - Basics of TALEN - Part A

Lecture 15 - Basics of TALEN - Part B

Lecture 16 - Design of TALEN for genome editing - Part A

Lecture 17 - Design of TALEN for genome editing - Part B

Lecture 18 - Application of TALEN - Part A

Lecture 19 - Application of TALEN - Part B

Lecture 20 - CRISPR system in bacteria - Part A

Lecture 21 - CRISPR system in bacteria - Part B

Lecture 22 - CRISPR/Cas9 in Genome Editing - Part A

Lecture 23 - CRISPR/Cas9 in Genome Editing - Part B

Lecture 24 - Applications of CRISPR/Cas9 - Part A

Lecture 25 - Applications of CRISPR/Cas9 - Part B

Lecture 26 - Computational Resources for CRISPR / Cas - Part A

Lecture 27 - Computational Resources for CRISPR / Cas - Part B

Lecture 28 - Human cell engineering in diseases : Thalassemia - Part A

Lecture 29 - Human cell engineering in diseases : Thalassemia - Part B

Lecture 30 - Human cell engineering in diseases : Severe combined immunodeficiency (SCID) - Part A

Lecture 31 - Human cell engineering in diseases : Severe combined immunodeficiency (SCID) - Part B

Lecture 32 - Human cell engineering in diseases : Hemophilia - Part A

Lecture 33 - Human cell engineering in diseases : Hemophilia - Part B

Lecture 34 - Animal models - Part A

Lecture 35 - Animal models - Part B

Lecture 36 - iPSc models - Part A

Lecture 37 - iPSc models - Part B

Lecture 38 - Cancer disease models - Part A

Lecture 39 - Cancer disease models - Part B

Lecture 40 - Engineered immune cells for Cancer therapy (I) - Part A

Lecture 41 - Engineered immune cells for Cancer therapy (I) - Part B

Lecture 42 - Engineered immune cells for Cancer therapy (II) - Part A

Lecture 43 - Engineered immune cells for Cancer therapy (II) - Part B

Lecture 44 - History and Basics - Part A

Lecture 45 - History and Basics - Part B

Lecture 46 - Genome editing and personalized therapy

Lecture 47 - Bioethics and Biosafety - Part A

Lecture 48 - Bioethics and Biosafety - Part B

Lecture 49 - Regulatory issues in Genome Editing