NPTEL : NOC:Structural Biology (Biotechnology)

Co-ordinators : Prof. Saugata Hazra


Lecture 1 - Introduction: Why to Study Structural Biology

Lecture 2 - Introduction to Biological Macromolecules

Lecture 3 - Introduction: Decoding Biological Macromolecules

Lecture 4 - Introduction: Genome Sequencing

Lecture 5 - Introduction: Post Genomic Era

Lecture 6 - Amino acids and their properties

Lecture 7 - Protein: Protein Chemistry, Chirality, Peptide bond and Levels of protein structures

Lecture 8 - Protein: Dihedral angles, Peptide bond and Ramachandran Plot

Lecture 9 - Protein: Super Secondary Structures, Motif, Domains, Non-covalent interactions

Lecture 10 - Protein: Folding of Protein, Thermodynamics and Kinetics of protein folding, Characterization of Proteins

Lecture 11 - Introduction to Structural Biology Techniques - Part I

Lecture 12 - Introduction to Structural Biology Techniques - Part II

Lecture 13 - X-ray Crystallography: Crystallization - Part I

Lecture 14 - X-ray Crystallography: Crystallization - Part II

Lecture 15 - X-ray Crystallography: Crystal Mounting

Lecture 16 - X-ray Crystallography: Production of X-ray and its properties

Lecture 17 - X-ray Crystallography: Journey to 3D land

Lecture 18 - X-ray Crystallography: Crystal Symmetry

Lecture 19 - X-ray Crystallography: Instrumentation in X-ray Crystallography

Lecture 20 - X-ray Crystallography: Data collection and processing

Lecture 21 - X-ray Crystallography: Data Analysis - Part I

Lecture 22 - X-ray Crystallography: Data Analysis - Part II

Lecture 23 - X-ray Crystallography: Phase Problem - Part I

Lecture 24 - X-ray Crystallography: Phase Problem - Part II

Lecture 25 - X-ray Crystallography: Refinement and Structure deposition to PDB

Lecture 26 - Introduction to Spectroscopy and NMR

Lecture 27 - Basic Principles of NMR and Instrumentation

Lecture 28 - NMR Sample Preparation and Chemical Shift related concepts

Lecture 29 - Factors effecting NMR Spectra (1D and 2D)

Lecture 30 - 2D and 3D NMR Spectroscopy focusing on protein structure

Lecture 31 - Introduction to Spectroscopy

Lecture 32 - UV-Vis and CD spectroscopy

Lecture 33 - Fluorescence Spectroscopy and Green Fluorescence Protein (GFP)

Lecture 34 - Infrared and Raman Spectroscopy for protein

Lecture 35 - Raman Spectroscopy, Raman Microscopy and Raman Crystallography for studying protein

Lecture 36 - Introduction to Microscopy

Lecture 37 - Functioning details of Cryo Electron Microscopy (Cryo EM)

Lecture 38 - Cryo Electron Microscopy: Data Collection and Analysis

Lecture 39 - A concise story of advancement Cryo-EM

Lecture 40 - Protein Data Bank

Lecture 41 - History of Molecular Visualizations of Biological Macromolecules

Lecture 42 - Description of structure related files (.pdb, .mmcif, .mtz, etc.)

Lecture 43 - Demonstration of COOT

Lecture 44 - 3D visualization using Pymol

Lecture 45 - Demonstration of Pymol

Lecture 46 - Why we need MD Simulation

Lecture 47 - Molecular Dynamic Simulation Process - Part I

Lecture 48 - Molecular Dynamic Simulation Process - Part II

Lecture 49 - Molecular Dynamic Simulation Process - Part III

Lecture 50 - Application of Molecular Dynamic Simulation

Lecture 51 - What, How and Which of Protein Engineering

Lecture 52 - How to make logical Protein Engineering: Process of Rational design

Lecture 53 - Success story of Rational Protein designing: Focusing on De Novo Process

Lecture 54 - Designing Protein by mimicking nature: Process of Directed Evolution

Lecture 55 - Achievement, Challenges, and Future direction in the field of Protein Engineering

Lecture 56 - Introduction to Structure Based Drug Discovery (SBDD)

Lecture 57 - Rational Drug Discovery

Lecture 58 - Docking Based Virtual Screening: Progress, Challenges and Future perspective

Lecture 59 - What makes a small molecule an ideal drug: Developing in silico ADMETox Model

Lecture 60 - Structure Based Drug Discovery: Case study and Conclusion