NPTEL : NOC:Computational Systems Biology (Biotechnology)

Co-ordinators : Prof. Karthik Raman


Lecture 1 - Introduction

Lecture 2 - Introduction to Modelling

Lecture 3 - Introduction to Modelling

Lecture 4 - Fundamentals of Mathematical Modelling

Lecture 5 - Fundamentals of Mathematical Modelling

Lecture 6 - Fundamentals of Mathematical Modelling

Lecture 7 - Some Example Models

Lecture 8 - Representation of Biological Networks

Lecture 9 - Lab: MATLAB Basics

Lecture 10 - Lab: MATLAB Basics

Lecture 11 - Lab: MATLAB Basics

Lecture 12 - Lab: MATLAB Basics

Lecture 13 - Introduction to Networks

Lecture 14 - Introduction to Networks

Lecture 15 - Introduction to Network Biology

Lecture 16 - Introduction to Network Biology

Lecture 17 - Introduction to Network Biology

Lecture 18 - Network Biology

Lecture 19 - Network Models

Lecture 20 - Network Models

Lecture 21 - Biological Networks

Lecture 22 - Network Perturbations

Lecture 23 - Community Detection

Lecture 24 - Network Motifs

Lecture 25 - Lab: Cytoscape

Lecture 26 - Lab: Cytoscape

Lecture 27 - Lab: Network Biology

Lecture 28 - Network Biology: Recap

Lecture 29 - Lab: Network Models and Perturbations

Lecture 30 - Lab: Network Models and Perturbations

Lecture 31 - Reconstruction of Gene Regulatory Networks

Lecture 32 - Reconstruction of Protein Networks

Lecture 33 - Reconstruction of Signalling Networks

Lecture 34 - Reconstruction of Signalling Networks

Lecture 35 - Introduction to Dynamic Modelling

Lecture 36 - Introduction to Dynamic Modelling

Lecture 37 - Introduction to Dynamic Modelling

Lecture 38 - Lab: Solving ODEs in MATLAB

Lecture 39 - Lab: Example Biological Model

Lecture 40 - Parameter Estimation

Lecture 41 - Parameter Estimation

Lecture 42 - Parameter Estimation

Lecture 43 - Methods for Parameter Estimation

Lecture 44 - Direct Search Methods

Lecture 45 - Genetic Algorithms

Lecture 46 - Genetic Algorithms

Lecture 47 - Other Evolutionary Algorithms

Lecture 48 - PyGMO

Lecture 49 - Dynamic Modelling Recap

Lecture 50 - Lab: Parameter Estimation

Lecture 51 - Guest Lecture: Modelling in Drug Development

Lecture 52 - Guest Lecture: Modelling in Drug Development

Lecture 53 - Guest Lecture: Quantitative Systems Pharmacology

Lecture 54 - Guest Lecture: Quantitative Systems Pharmacology

Lecture 55 - Guest Lecture: Quantitative Systems Pharmacology

Lecture 56 - Constraint-based Modelling of Metabolic Networks

Lecture 57 - Flux Balance Analysis

Lecture 58 - Flux Balance Analysis

Lecture 59 - Flux Balance Analysis

Lecture 60 - Other Constraint-Based Approaches

Lecture 61 - Other Constraint-Based Approaches

Lecture 62 - Lab: FBA using MATLAB

Lecture 63 - Perturbations to Metabolic Networks: Deletions

Lecture 64 - Lab: COBRA Toolbox

Lecture 65 - Understanding FBA

Lecture 66 - Understanding FBA

Lecture 67 - Perturbations to Metabolic Networks: Over-expression

Lecture 68 - Perturbations to Metabolic Networks: Synthetic Lethals

Lecture 69 - Perturbations to Metabolic Networks: Synthetic Lethals

Lecture 70 - Constraint-based Modelling of Metabolic Networks

Lecture 71 - Lab: Gene Deletions

Lecture 72 - Integrating Regulatory Information into Constraint-Based Models

Lecture 73 - Elementary Modes

Lecture 74 - Elementary Modes

Lecture 75 - Constraint-based Modelling of Metabolic Networks: Applications

Lecture 76 - Constraint-based Modelling of Metabolic Networks: Applications

Lecture 77 - Constraint-based Modelling of Metabolic Networks: Applications

Lecture 78 - Lab: Gene Deletions

Lecture 79 - Constraint-based Modelling of Metabolic Networks: Recap

Lecture 80 - Constraint-based Modelling of Metabolic Networks: Recap

Lecture 81 - Constraint-based Modelling of Metabolic Networks: Recap

Lecture 82 - $^{13}$C-Metabolic Flux Analysis using Mass Spectrometry

Lecture 83 - $^{13}$C-Metabolic Flux Analysis using Mass Spectrometry

Lecture 84 - $^{13}$C-Metabolic Flux Analysis using Mass Spectrometry

Lecture 85 - Lab: $^{13}$C-Metabolic Flux Analysis using Mass Spectrometry

Lecture 86 - Modelling Gene Regulatory Networks

Lecture 87 - Modelling Gene Regulatory Networks

Lecture 88 - Modelling Gene Regulatory Networks

Lecture 89 - Lab: Modelling Gene Regulatory Networks

Lecture 90 - Lab: Modelling Gene Regulatory Networks

Lecture 91 - Computational Modelling of Host-Pathogen Interactions

Lecture 92 - Computational Modelling of Host-Pathogen Interactions

Lecture 93 - Robustness in Biological Systems

Lecture 94 - Robustness in Biological Systems: Mechanisms

Lecture 95 - Robustness in Biological Systems: Organising Principles

Lecture 96 - Robustness in Biological Systems: Trade-offs

Lecture 97 - Obustness and Evolvability

Lecture 98 - obustness and Evolvability

Lecture 99 - Introduction to Synthetic Biology

Lecture 100 - Advanced Topics

Lecture 101 - Advanced Topics

Lecture 102 - Advanced Topics

Lecture 103 - Course Recap